Induction of protooncogene c-jun by serum growth factors.

作者：Kevin Ryder, Daniel Nathans · 发表于：Proceedings of the National Academy of Sciences · 年份：1988 · DOI：10.1073/pnas.85.22.8464 · 被引用次数：438 · 研究领域：Hormonal Regulation and Hypertension、Pharmacogenetics and Drug Metabolism、Coenzyme Q10 studies and effects

We have previously reported that one of the genes that is rapidly induced in mouse 3T3 cells by serum growth factors (jun-B) encodes a protein related to the onco-protein v-jun. By using jun-B as a probe, we have isolated a cDNA encoding a second member of the jun family (jun-A) that is the murine version of the protooncogene c-jun, which encodes the mammalian transcription factor AP-1. jun-B and jun-A (c-jun) have two highly conserved regions and two regions with little sequence similarity. Like jun-B, jun-A (c-jun) is rapidly activated by serum, platelet-derived growth factor, or fibroblast growth factor and is superinduced by serum in the presence of an inhibitor of protein synthesis. Both jun proteins are likely to play a role in regulating the genetic program induced by growth factors.