MyoD and the regulation of myogenesis by helix-loop-helix proteins.

作者：Stephen J. Tapscott, H Weintraub · 发表于：Journal of Clinical Investigation · 年份：1991 · DOI：10.1172/jci115109 · 被引用次数：142 · 研究领域：Muscle Physiology and Disorders、Mitochondrial Function and Pathology、CRISPR and Genetic Engineering

The MyoD protein is sufficient to orchestrate the coordinated expression of most, if not all, ofthe skeletal myogenic program in cell types derived from all three germ layers of the embryo.As such the regulation ofMyoD expression and protein activity creates a nodal point, or master switch, that integrates the ge- netic and environmental influences on a cell.The expression and activity ofthe MyoD protein is regulated, in part, by inter- action with members of a large family of proteins related to MyoD by sequence homology, the helix-loop-helix (HLH)' proteins.This review will focus on the regulation of skeletal myogenesis by MyoD and related myogenic HLH proteins.