An Early Event in the Interferon-Induced Transmembrane Signaling Process

作者：W. H. Yap, T. S. Teo, Yuwei Tan · 发表于：Science · 年份：1986 · DOI：10.1126/science.2429366 · 被引用次数：90 · 研究领域：Immune Response and Inflammation、Neutrophil, Myeloperoxidase and Oxidative Mechanisms、interferon and immune responses

Human interferon stimulates a transient two- to threefold increase in the concentration of diacylglycerol and inositol tris-phosphate within 15 to 30 seconds of cell exposure to interferon. Antibodies to interferon inhibit this effect. The stimulation was measurable in isolated cell membranes exposed to interferon. Human alpha and beta, but not gamma, interferon stimulate this increase in cells containing the appropriate interferon receptor. The effect was proportional to the number of interferon receptors. Both the diacylglycerol increase and antiviral effects induced by interferon could be correlated in terms of dose dependence. Thus, a transient diacylglycerol increase is an early event in the interferon-induced transmembrane signaling process.