Hsp27: Novel Regulator of Intracellular Redox State

作者：André‐Patrick Arrigo · 发表于：IUBMB Life · 年份：2001 · DOI：10.1080/152165401317291156 · 被引用次数：173 · 研究领域：Heat shock proteins research、Endoplasmic Reticulum Stress and Disease、Redox biology and oxidative stress

Small stress proteins are molecular chaperones that modulate the ability of cells to respond to several types of injuries. In this regard, a protection generated by the expression of mammalian small stress proteins against the cell death induced by oxidative stress has been described. This review summarizes the current knowledge of the protective mechanism generated by the expression of the major mammalian small stress protein Hsp27 in cells exposed to oxidative stress. A possible role of this chaperone protein in the presentation of oxidized proteins to the proteasome degradation machinery is proposed.