Hypertension and Associated Metabolic Abnormalities — The Role of Insulin Resistance and the Sympathoadrenal System

作者：Gerald M. Reaven, Hans Lithell, Lewis Landsberg · 发表于：New England Journal of Medicine · 年份：1996 · DOI：10.1056/nejm199602083340607 · 被引用次数：1451 · 研究领域：Blood Pressure and Hypertension Studies、Diabetes, Cardiovascular Risks, and Lipoproteins、Liver Disease Diagnosis and Treatment

Abnormalities of glucose, insulin, and lipoprotein metabolism are common in patients with hypertension. These changes can also be discerned in normotensive first-degree relatives of hypertensive patients. They are not present in patients with secondary forms of hypertension, do not necessarily improve when blood pressure is lowered pharmacologically, and may even be made worse by some forms of antihypertensive treatment. These metabolic abnormalities may play a part in both the pathogenesis and the complications of hypertension in many patients. We hypothesize that the metabolic abnormalities are linked to the hypertension by a pathophysiologic process that involves the sympathoadrenal system and exerts . . .