Granulocyte collagenase: selective digestion of type I relative to type III collagen.

作者：Allen L. Horwitz, A J Hance, Ronald G. Crystal · 发表于：Proceedings of the National Academy of Sciences · 年份：1977 · DOI：10.1073/pnas.74.3.897 · 被引用次数：204 · 研究领域：Connective tissue disorders research、Protease and Inhibitor Mechanisms、Blood Coagulation and Thrombosis Mechanisms

Collagenases produced by human polymorphonuclear leukocytes, human lung fibroblasts, and rabbit pulmonary alveolar macrophages were compared in their ability to digest soluble native type I and type III collagens. While the fibroblast and macrophage collagenases attacked the two substrates at approximately equal rates, the leukocyte collagenase attacked type I collagen preferentially (15:1) in comparison to type III collagen. This was true with human or rabbit collagen substrates. Thus, proteolysis of collagen, particularly in acute inflammation, may have a significant role in controlling the types of collagen present in connective tissue.