Possible methionine biosynthesis inhibition by pyrimidinamine fungicides

作者：Petr Masner, Peter Muster, Jacqueline Schmid · 发表于：Pesticide Science · 年份：1994 · DOI：10.1002/ps.2780420304 · 被引用次数：148 · 研究领域：Fungal Plant Pathogen Control、Plant Disease Resistance and Genetics、Pesticide and Herbicide Environmental Studies

Abstract The broad‐spectrum fungicide CGA 219417 inhibits mycelial growth of Botrytis cinerea Pers ex Fr. Pseudocercosporella herpotrichoides (Fron.) Deighton and Helminthosporium oryzae B. de Haan on defined media lacking amino acids. The growth inhibition of B. cinerea is reversed by the addition of a mixture of 19 amino acids at a concentration of 100 μM each or by the addition of methionine or homocysteine in concentrations of 100 μM or 1 mM, respectively. In the case of B. cinerea, the reversal of growth inhibition by methionine could also be shown for pyrimethanil and mepanipyrim. These findings suggest that the pyrimidinamine fungicides inhibit the biosynthesis of methionine in phytopathogenic fungi.