Herpes Simplex Virus Type 1 DNA in Cerebrospinal Fluid of a Patient with Mollaret's Meningitis

作者：Linda J. Yamamoto, Davol G. Tedder, Rhoda L. Ashley, Myron J. Levin · 发表于：New England Journal of Medicine · 年份：1991 · DOI：10.1056/nejm199110103251507 · 被引用次数：119 · 研究领域：Herpesvirus Infections and Treatments、Cytomegalovirus and herpesvirus research、Bartonella species infections research

MOLLARET'S meningitis is a rare disease characterized by recurrent, self-limited episodes of aseptic meningitis.1 Signs and symptoms of meningeal irritation appear acutely, in association with fever and pleocytosis of mononuclear cells. These episodes last two to five days or occasionally longer and remit spontaneously.2–6 Five to 15 attacks may occur, separated by symptom-free intervals of weeks to months. Transient neurologic abnormalities may be present during the attacks, but they disappear after the acute illness. The diagnosis of Mollaret's meningitis is made only after other recognized causes of recurrent lymphocytic meningitis have been excluded.2 Numerous attempts to establish a microbiologic cause . . .