Eosinophilic Xanthomatous Granuloma with Honeycomb Lungs

作者：T. Parkinson · 发表于：BMJ · 年份：1949 · DOI：10.1136/bmj.1.4614.1029 · 被引用次数：61 · 研究领域：Histiocytic Disorders and Treatments、Eosinophilic Disorders and Syndromes

The precise nature of the Hand-Schuller-Christian syndrome is unknown.Originally it was thought that the various pathological changes were specific, and that they were due to abnormal intracellular lipoid metabolism (Thannhauser, 1940).More recently it has been realized that the disease is probably a phase in a generalized disorder of the reticulo-endothelial system, and that it has certain features in common with eosinophilic granuloma of bone.The following case is reported as an example of the transition between these two diseases, and because, in addition to the recognized bony and pituitary manifesta- tions, it shows pulmonary infiltration and polycystic, or honeycomb, lungs.So far as is known, no similar case has been reported from this country, and the occurrence of the disease in a subject of the patient's age is unique. Case HistoryA boot-repairer aged 56 was admitted in September, 1948.In 1942 he had begun to notice breathlessness on exertion, and this symptom progressed slowly until his admission.In 1942