Caloric Restriction Delays Disease Onset and Mortality in Rhesus Monkeys

作者：Ricki J. Colman, Rozalyn M. Anderson, Sterling C. Johnson, Erik K. Kastman, Kristopher J. Kosmatka, Timothy Mark Beasley, David Blair Allison, Christina Cruzen, Heather A. Simmons, Joseph W. Kemnitz, Richard H. Weindruch · 发表于：Science · 年份：2009 · DOI：10.1126/science.1173635 · 被引用次数：2308 · 研究领域：Genetics, Aging, and Longevity in Model Organisms、Adipose Tissue and Metabolism、Tryptophan and brain disorders

Caloric restriction (CR), without malnutrition, delays aging and extends life span in diverse species; however, its effect on resistance to illness and mortality in primates has not been clearly established. We report findings of a 20-year longitudinal adult-onset CR study in rhesus monkeys aimed at filling this critical gap in aging research. In a population of rhesus macaques maintained at the Wisconsin National Primate Research Center, moderate CR lowered the incidence of aging-related deaths. At the time point reported, 50% of control fed animals survived as compared with 80% of the CR animals. Furthermore, CR delayed the onset of age-associated pathologies. Specifically, CR reduced the incidence of diabetes, cancer, cardiovascular disease, and brain atrophy. These data demonstrate that CR slows aging in a primate species.