Islet‐activating protein, pertussis toxin, inhibits Ca2+‐induced and guanine nucleotide‐dependent releases of histamine and arachidonic acid from rat mast cells

作者：T. Nakamura, Michio Ui · 发表于：FEBS Letters · 年份：1984 · DOI：10.1016/0014-5793(84)80816-9 · 被引用次数：96 · 研究领域：Mast cells and histamine、Receptor Mechanisms and Signaling、Adenosine and Purinergic Signaling

Islet-activating protein (IAP) suppressed Ca2+-induced histamine release and phospholipase A2 activation in Gpp(NH)p-loaded mast cells. Since the guanine nucleotide-binding protein involved in adenylate cyclase inhibition is known to lose its function upon being ADP-ribosylated by IAP, the nucleotide-binding protein is likely to mediate Ca2+-linked biosignalling leading to histamine secretion.