Rhabdomyosarcoma in adults

作者：Andrea C. Ferrari, Palma Dileo, Michela Casanova, Rossella Bertulli, Cristina Meazza, Lorenza Gandola, Pierina Navarria, Paola Collini, Alessandro Gronchi, Patrizia Olmi, Franca Fossati‐Bellani, Paolo Giovanni Casali · 发表于：Cancer · 年份：2003 · DOI：10.1002/cncr.11550 · 被引用次数：403 · 研究领域：Sarcoma Diagnosis and Treatment、Metastasis and carcinoma case studies、Bone Tumor Diagnosis and Treatments

BACKGROUND: The goal of the current study was to clarify treatment outcomes for adult patients with rhabdomyosarcoma (RMS). Published series have reported definitively worse results for adults with RMS compared with children with RMS. This finding casts doubt on whether RMS is the same disease in adults as it is in children. METHODS: Of 190 patients with RMS who were age 18 years or older and whose cases were recorded over a 25-year span in the pathology database of the Istituto Nazionale Tumori (Milan, Italy), 171 could be analyzed retrospectively for treatment outcome. The authors attempted to stratify patients according to the degree to which they had been treated appropriately, based on current treatment guidelines for childhood RMS. RESULTS: The overall rate of response to chemotherapy was 85%. For the entire series, 5-year event-free survival and 5-year overall survival (OS) were 28% and 40%, respectively. Among the 110 patients with embryonal, alveolar, or 'not otherwise specified' RMS, 5-year OS was 46%; however, 5-year OS was 61% for patients within this group (39% of the total) who had high scores for appropriate treatment. CONCLUSIONS: The current series parallels other published series in that it confirms the finding of a relatively poor long-term outcome for adult patients with RMS. However, for patients whose treatment adhered to the current guidelines for treatment of children, outcome was similar to what has been reported in pediatric series. In addition, the ...