Gender Differences in the Risk Factors for Endothelial Dysfunction in Chinese Hypertensive Patients: Homocysteine Is an Independent Risk Factor in Females

作者：Cheng Cao, Jianxin Hu, Yifei Dong, Rui Zhan, Ping Li, Hai Su, Qiang Peng, Tao Wu, Liang Lei, Xiao Huang, Qinghua Wu, Xiaoshu Cheng · 发表于：PLoS ONE · 年份：2015 · DOI：10.1371/journal.pone.0118686 · 被引用次数：24 · 研究领域：Folate and B Vitamins Research、Cardiovascular Health and Disease Prevention、Nitric Oxide and Endothelin Effects

OBJECTIVES: Endothelial dysfunction plays a key role in the pathogenesis of cardiovascular disease. However, the gender-related differences in risk factors for endothelial dysfunction are controversial. We investigated the gender differences in the risk factor profiles for endothelial dysfunction in Chinese hypertensive patients. METHODS: Vascular endothelial functions in 213 hypertensive patients were measured by digital reactive hyperemia peripheral arterial tonometry (RH-PAT). Peripheral blood samples were collected, and the self-reported smoking and alcohol consumption status, age, body mass index, heart rate, blood pressure and drug administrations were recorded. RESULTS: RH-PAT indexes were attenuated in both male and female hypertensive patients [1.60 (1.38-2.02) vs. 1.63 (1.44-1.98)]. Multivariate logistic regression analysis identified plasma creatinine (p < 0.001), total cholesterol (p = 0.001), homocysteine (p = 0.002) and smoking (p < 0.001) as the independent factors correlated with gender (male). Multivariate linear regression analysis further identified homocysteine as the factor that is significantly and independently correlated with the decrease in the RH-PAT indexes in female patients (odds ratio: -0.166, 95% confidence interval: -0.292 to -0.040, p = 0.01). However, none of these four factors were correlated with the RH-PAT indexes in male patients. CONCLUSIONS: There are gender-related differences in the risk factors for endothelial dysfunction in Chinese ...