Gentamicin and Neuromuscular Blockade

作者：Jordan L. Holtzman · 发表于：Annals of Internal Medicine · 年份：1976 · DOI：10.7326/0003-4819-84-1-55_1 · 被引用次数：31 · 研究领域：Antibiotics Pharmacokinetics and Efficacy、Anesthesia and Sedative Agents、Pharmaceutical studies and practices

Letters1 January 1976Gentamicin and Neuromuscular BlockadeJORDAN L. HOLTZMAN, M.D., PH.D.JORDAN L. HOLTZMAN, M.D., PH.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-84-1-55_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptNeuromuscular blockade is a major toxicity of amino-glycoside antibiotics (1, 2). Yet gentamicin has only rarely been associated with blockade (3, 4). Warner and Sanders (3) reported on a patient who had 14 days of gentamicin and then a laparotomy during which he received curare. Forty-eight hours later he had respiratory arrest attributed to gentamicin neuromuscular blockade. Similarly Hall and associates (4) reported on a uremic patient who had neuromuscular blockade after tubocurarine, lidocaine, and gentamicin, suggesting an additive effect of these agents (5). We recently observed a patient with severe Parkinson's disease who on two occasions exhibited a profound...References1. MOLITORGRAESSLE HO: Pharmacology and toxicology of antibiotics. Pharmacol Rev 2:1-60, 1950 Google Scholar2. BRAZILCORRADO OA: The curariform action of streptomycin. J Pharmacol Exp Ther 120:452-459, 1957 MedlineGoogle Scholar3. WARNERSANDERS WE: Neuromuscular blockade associated with gentamicin. JAMA 215:1153-1154, 1971 CrossrefMedlineGoogle Scholar4. HALLMCGIBBONEVANS DDC: Gentamicin, tubocurarine, lidocaine and neuromuscular blo...