Amyloid is linked to cognitive decline in patients with Parkinson disease without dementia

作者：Stephen N. Gomperts, Joseph J. Locascio, Dorene M. Rentz, Andrea Santarlasci, Marta Marquié, Keith A. Johnson, John H. Growdon · 发表于：Neurology · 年份：2012 · DOI：10.1212/wnl.0b013e31827b1a07 · 被引用次数：184 · 研究领域：Parkinson's Disease Mechanisms and Treatments、Dementia and Cognitive Impairment Research、Alzheimer's disease research and treatments

OBJECTIVE: To determine whether amyloid burden, as indexed by Pittsburgh compound B (PiB) retention, identifies patients with Parkinson disease with mild cognitive impairment (PD-MCI) compared to those with normal cognition (PD-nl). A related aim is to determine whether amyloid burden predicts cognitive decline in a cohort of subjects with PD without dementia. METHODS: In this prospective cohort study, we examined 46 subjects with PD without dementia, of whom 35 had normal cognition and 11 met criteria for PD-MCI at study baseline. All subjects underwent standardized neurologic and neuropsychological examinations and PiB PET at baseline, and clinical examinations were conducted annually for up to 5 years. RESULTS: At baseline, precuneus PiB retention did not distinguish PD-MCI from PD-nl. Subjects with PD-MCI declined more rapidly than PD-nl subjects on cognitive tests of memory, executive function, and activation retrieval. Of the 35 PD-nl subjects, 8 progressed to PD-MCI and 1 to dementia; of the 11 PD-MCI subjects, 5 converted to dementia. Both higher PiB retention and a diagnosis of PD-MCI predicted a greater hazard of conversion to a more severe diagnosis. Baseline PiB retention predicted worsening in executive function over time. The APOE ε4 allele also related to worsening in executive function, as well as visuospatial function, activation retrieval, and performance on the Mini-Mental State Examination. In contrast to its relation to cognitive decline, PiB retention di...