Chronic gastritis and gastric ulcer

作者：Ian R. Mackay, Ian G. Hislop · 发表于：Gut · 年份：1966 · DOI：10.1136/gut.7.3.228 · 被引用次数：40 · 研究领域：Helicobacter pylori-related gastroenterology studies、Gastrointestinal motility and disorders、Diabetes Treatment and Management

The authors focus attention on the possible role of chronic gastritis as a cause of gastric ulceration and bleeding resulting from decreased mucosal resistance.Duodenal and gastric antral ulcers differ in certain respects from ulcers in the body of the stomach.Thus with duodenal and gastric antral ulcers there is a high gastric acidity, a large parietal cell mass, and a histologically normal gastric mucosa (Cox, 1952; Ball, 1961), whereas with gastric ulcers there is a normal, low, or even greatly reduced, gastric acid secretion (Levin, Kirsner, Palmer, and Butler, 1948; Morlock and Ratke, 1949; Ball, 1961; Baron, 1963), a reduced parietal cell mass, and often a histologically abnormal gastric mucosa with changes of gastritis (Magnus, 1952; Ball and James, 1961).Hence 'decreased mucosal resistance' rather than hyperacidity is claimed to be the important factor in the pathogenesis of gastric ulcer (Illingworth, 1956; Marks and Shay, 1959).This paper describes nine patients in whom gastric ulceration and/or bleeding occurred as a complication of active chronic gastritis: the concept is presented that pre-existing chronic gastritis, in representing one cause of decreased mucosal resistance, is of importance in the pathogenesis of gastric ulceration.