Histone modifying enzymes and cancer: Going beyond histones

作者：Ke Zhang, Sharon Dent · 发表于：Journal of Cellular Biochemistry · 年份：2005 · DOI：10.1002/jcb.20615 · 被引用次数：155 · 研究领域：Epigenetics and DNA Methylation、Histone Deacetylase Inhibitors Research、Genomics and Chromatin Dynamics

Mutations in the molecular pathways that regulate cell proliferation, differentiation, and cell death all contribute to cancer formation. Enzymes that covalently modify histones affect these pathways by controlling the dynamic remodeling of chromatin structure. This article reviews several connections between histone modifying enzymes and cancer that are likely mediated via both histone and non-histone substrates. We propose that multiple protein modifications, including phosphorylation, methylation, and acetylation, cross regulate one another to coordinate intermolecular signaling, and that miscues in this regulation can lead to oncogenesis.