Donor safety and remnant liver volume in living donor liver transplantation

作者：C. Burcin Taner, Murat Dayangaç, Barış Akin, Deniz Balcı, Süleyman Uraz, Cihan Duran, Refik Killi, Ömer Ayanoğlu, Yıldıray Yüzer, Yaman Tokat · 发表于：Liver Transplantation · 年份：2008 · DOI：10.1002/lt.21562 · 被引用次数：85 · 研究领域：Organ Transplantation Techniques and Outcomes、Liver Disease and Transplantation、Organ Donation and Transplantation

Living donor liver transplantation is now a common practice in countries in which the availability of cadaveric organs is limited. The preoperative preparation, intraoperative surgical technique, and postoperative care of donors and recipients have evolved in recent years. We retrospectively compared 67 donors with a remnant liver volume equal to or more than 30% (group 1) with 14 donors who had less than 30% remnant liver volume (group 2) for donor outcomes. All the complications in donors were systematically classified. Donors with less than 30% remnant liver volume showed significantly higher peak aspartate aminotransferase, alanine aminotransferase, international normalized ratio, and bilirubin levels. There were 6 complications in group 1 and 4 complications in group 2. The difference between the 2 groups in terms of donor complications did reach statistical significance (P = 0.043); donors with a remnant liver volume < 30% had a 4 times greater relative risk of morbidity. In conclusion, the use of donors with less than 30% remnant liver volume is highly debatable as donor safety should be of utmost importance in living donor liver transplantation.