Reevaluation of prognostic factors for survival after liver resection in patients with hepatocellular carcinoma in a Japanese nationwide survey

作者：Iwao Ikai, Shigeki Arii, Masamichi Kojiro, Takafumi Ichida, Masatoshi Makuuchi, Yutaka Matsuyama, Yasuni Nakanuma, Kiwamu Okita, Masao Omata, Kenichi Takayasu, Yoshio Yamaoka, The Liver Cancer Study Group of Japan · 发表于：Cancer · 年份：2004 · DOI：10.1002/cncr.20426 · 被引用次数：456 · 研究领域：Hepatocellular Carcinoma Treatment and Prognosis、Pancreatic and Hepatic Oncology Research、Cancer Research and Treatments

BACKGROUND: Advances in the diagnosis and surgical treatment of hepatocellular carcinoma (HCC) have improved the prognosis for patients with HCC who undergo liver resection. The objective of this study was to evaluate prognostic predictors for patients with HCC who underwent liver resection in a Japanese nationwide data base. METHODS: In this study, the authors analyzed 12,118 patients with HCC in a Japanese nationwide data base who underwent liver resection between 1990 and 1999 and compared them with a previous analysis of patients between 1982 and 1989. All patients were evaluated for prognostic factors. RESULTS: During the last decade, the increases in patients who were without hepatitis B virus surface antigen, who had small tumors, and who had portal vein invasion were noted. The 5-year overall survival rates for patients with HCC improved to 50.5%, compared with < 40% in the previous analysis. A multivariate analysis using a stratified Cox proportional hazards model according to associated liver disease indicated that age, degree of liver damage, alpha-fetoprotein level, maximal tumor dimension, number of tumors, intrahepatic extent of tumor, extrahepatic metastasis, portal vein invasion, hepatic vein invasion, surgical curability, and free surgical margins were independent prognostic predictors for patients with HCC. Operative mortality decreased from 2.3% in 1990-1991 to 0.6% in 1998-1999. CONCLUSIONS: Outcomes and operative mortality rates in patients with HCC impro...