An adipocyte-central nervous system regulatory loop in the control of adipose homeostasis

作者：Thomas M. Loftus · 发表于：Seminars in Cell and Developmental Biology · 年份：1999 · DOI：10.1006/scdb.1998.0274 · 被引用次数：40 · 研究领域：Regulation of Appetite and Obesity、Adipose Tissue and Metabolism

Mounting evidence supports a 'lipostatic' model for the regulation of adipose mass. In such a model, signals are generated in the periphery in proportion to adipose mass that act on hypothalamic control centers in the brain to regulate food intake and energy expenditure. Two such signals, leptin and insulin, have been identified and found to dramatically lower food intake and body weight. Several signalling molecules in the effector pathways that mediate the response to these signals in the brain have also been identified. The regulation of these factors and the nature of the adipose-CNS regulatory loop will be discussed.