Appearance of an Early “Primed State” in Mice following the Concomitant Injections of Antigen and Specific Antiserum

作者：Geronimo Terres, Sherie Leaver Morrison, Gail S. Habicht, Richard D. Stoner · 发表于：The Journal of Immunology · 年份：1972 · DOI：10.4049/jimmunol.108.6.1473 · 被引用次数：28 · 研究领域：Immune Response and Inflammation、Protein purification and stability、Monoclonal and Polyclonal Antibodies Research

Abstract Injection of mice with immune complexes formed with bovine serum albumin (BSA) and rabbit anti-BSA in antigen excess produced an enhanced anti-BSA response. An enhanced antibody response was also obtained when immune complexes prepared at equivalence were injected intravenously and a second antigen injection was made within 4 days. The results suggest that immune complexes elicit within a few days a “primed state” which is identical to the primed state observed weeks after a single antigen injection; that is, the kinetics of the appearance of antibody and the effect of whole-body irradiation upon the antibody response following the second antigen injection were similar to those observed in mice primed with antigen alone. The role of antibody and antigen-antibody complexes in eliciting a primed state is discussed.