Cognitive impairment and resting-state network connectivity in Parkinson's disease

作者：Hugo C. Baggio, Bàrbara Segura, Roser Sala‐Llonch, María‐José Martí, Francesc Valldeoriola, Yaroslau Compta, Eduardo Tolosa, Carme Junqué · 发表于：Human Brain Mapping · 年份：2014 · DOI：10.1002/hbm.22622 · 被引用次数：324 · 研究领域：Functional Brain Connectivity Studies、Advanced Neuroimaging Techniques and Applications、Advanced MRI Techniques and Applications

The purpose of this work was to evaluate changes in the connectivity patterns of a set of cognitively relevant, dynamically interrelated brain networks in association with cognitive deficits in Parkinson's disease (PD) using resting-state functional MRI. Sixty-five nondemented PD patients and 36 matched healthy controls were included. Thirty-four percent of PD patients were classified as having mild cognitive impairment (MCI) based on performance in attention/executive, visuospatial/visuoperceptual (VS/VP) and memory functions. A data-driven approach using independent component analysis (ICA) was used to identify the default-mode network (DMN), the dorsal attention network (DAN) and the bilateral frontoparietal networks (FPN), which were compared between groups using a dual-regression approach controlling for gray matter atrophy. Additional seed-based analyses using a priori defined regions of interest were used to characterize local changes in intranetwork and internetwork connectivity. Structural group comparisons through voxel-based morphometry and cortical thickness were additionally performed to assess associated gray matter atrophy. ICA results revealed reduced connectivity between the DAN and right frontoinsular regions in MCI patients, associated with worse performance in attention/executive functions. The DMN displayed increased connectivity with medial and lateral occipito-parietal regions in MCI patients, associated with worse VS/VP performance, and with occipital ...