Recent insights into the cellular biology of atherosclerosis

作者：Ira Tabas, Guillermo García‐Cardeña, Gary K. Owens · 发表于：The Journal of Cell Biology · 年份：2015 · DOI：10.1083/jcb.201412052 · 被引用次数：1020 · 研究领域：Atherosclerosis and Cardiovascular Diseases、Adipokines, Inflammation, and Metabolic Diseases、Caveolin-1 and cellular processes

Atherosclerosis occurs in the subendothelial space (intima) of medium-sized arteries at regions of disturbed blood flow and is triggered by an interplay between endothelial dysfunction and subendothelial lipoprotein retention. Over time, this process stimulates a nonresolving inflammatory response that can cause intimal destruction, arterial thrombosis, and end-organ ischemia. Recent advances highlight important cell biological atherogenic processes, including mechanotransduction and inflammatory processes in endothelial cells, origins and contributions of lesional macrophages, and origins and phenotypic switching of lesional smooth muscle cells. These advances illustrate how in-depth mechanistic knowledge of the cellular pathobiology of atherosclerosis can lead to new ideas for therapy.