Molecular physiology of reverse cholesterol transport.

作者：C J Fielding, P E Fielding · 发表于：Journal of Lipid Research · 年份：1995 · DOI：10.1016/s0022-2275(20)39898-9 · 被引用次数：1454 · 研究领域：Cholesterol and Lipid Metabolism、Drug Transport and Resistance Mechanisms、Cancer, Lipids, and Metabolism

Reverse cholesterol transport (RCT) is the pathway by which peripheral cell cholesterol can be returned to the liver for catabolism. Evidence of specific functions for molecular structures within individual plasma lipoprotein species has rapidly accumulated from recent studies using molecular and cellular physiology techniques. The removal of cholesterol from cells, like its delivery, appears to be specific and well regulated. Although further research will be needed, RCT can now be understood in molecular terms.