Strategies for Multivessel Revascularization in Patients with Diabetes

作者：Michael E. Farkouh, Michaël Domanski, Lynn A. Sleeper, Flora S. Siami, George Dangas, Michael J. Mack, May Yang, David J. Cohen, Yves Rosenberg, Scott D. Solomon, Akshay S. Desai, Bernard J. Gersh, Elizabeth A. Magnuson, Alexandra J. Lansky, Robin Boineau, Jesse Weinberger, Krishnan Ramanathan, J. Eduardo Sousa, Jamie Rankin, Balram Bhargava, John B. Buse, Whady Hueb, Craig R. Smith, Victoria Muratov, Sameer Bansilal, Spencer B. King, Michel E. Bertrand, Valentı́n Fuster · 发表于：New England Journal of Medicine · 年份：2012 · DOI：10.1056/nejmoa1211585 · 被引用次数：1932 · 研究领域：Coronary Interventions and Diagnostics、Peripheral Artery Disease Management、Cerebrovascular and Carotid Artery Diseases

BACKGROUND: In some randomized trials comparing revascularization strategies for patients with diabetes, coronary-artery bypass grafting (CABG) has had a better outcome than percutaneous coronary intervention (PCI). We sought to discover whether aggressive medical therapy and the use of drug-eluting stents could alter the revascularization approach for patients with diabetes and multivessel coronary artery disease. METHODS: In this randomized trial, we assigned patients with diabetes and multivessel coronary artery disease to undergo either PCI with drug-eluting stents or CABG. The patients were followed for a minimum of 2 years (median among survivors, 3.8 years). All patients were prescribed currently recommended medical therapies for the control of low-density lipoprotein cholesterol, systolic blood pressure, and glycated hemoglobin. The primary outcome measure was a composite of death from any cause, nonfatal myocardial infarction, or nonfatal stroke. RESULTS: From 2005 through 2010, we enrolled 1900 patients at 140 international centers. The patients' mean age was 63.1±9.1 years, 29% were women, and 83% had three-vessel disease. The primary outcome occurred more frequently in the PCI group (P=0.005), with 5-year rates of 26.6% in the PCI group and 18.7% in the CABG group. The benefit of CABG was driven by differences in rates of both myocardial infarction (P<0.001) and death from any cause (P=0.049). Stroke was more frequent in the CABG group, with 5-year rates of 2.4% i...