Characteristics of 10-Year Survivors of Pancreatic Ductal Adenocarcinoma

作者：Alessandro Paniccia, Patrick W. Hosokawa, William G. Henderson, Richard David Schulick, Barish H. Edil, Martin D. McCarter, Csaba Gajdos · 发表于：JAMA Surgery · 年份：2015 · DOI：10.1001/jamasurg.2015.0668 · 被引用次数：191 · 研究领域：Pancreatic and Hepatic Oncology Research、Multiple and Secondary Primary Cancers、Cholangiocarcinoma and Gallbladder Cancer Studies

IMPORTANCE: To our knowledge, this study reports on the largest cohort of long-term survivors (LTSs) (≥10 years) following a diagnosis of pancreatic ductal adenocarcinoma (PADC) and identifies the characteristics associated with LTS. OBJECTIVE: To determine patient, tumor, surgical, and sociodemographic characteristics associated with LTS. DESIGN, SETTING, AND PARTICIPANTS: A nationwide retrospective cohort study of patients with invasive PADC (International Classification of Diseases for Oncology, Third Edition codes 8140/3, 8500/3, 8021/3, and 8035/3) was conducted using data collected in the National Cancer Database (NCDB). A multivariable logistic regression model of factors significantly associated with LTS was developed and used to generate a nomogram predicting the likelihood of surviving at least 10 years from initial diagnosis. Data collected from more than 1500 academic centers and community hospitals in the United States and Puerto Rico were assessed. Patients included were those with histologically proven PADC who underwent pancreatic surgical resection aimed at removal of the primary tumor between January 1, 1998, and December 31, 2002 (n = 11,917). The initial cohort (n = 70,915) excluded noninvasive tumors or tumors with unknown histology (n = 11,696) and was limited to patients who underwent surgical resection (n = 47,302 excluded). Analysis was conducted from January 1, 1998, to December 31, 2011. EXPOSURES: Pancreatic ductal adenocarcinoma. MAIN OUTCOMES AND...