Association between NF-κBI and NF-κBIA polymorphisms and coronary artery disease

作者：Serdal Arslan, Özge Korkmaz, Nil Özbilüm Şahin, Öcal Berkan · 发表于：Biomedical Reports · 年份：2015 · DOI：10.3892/br.2015.499 · 被引用次数：9 · 研究领域：NF-κB Signaling Pathways、Immune Response and Inflammation、Peroxisome Proliferator-Activated Receptors

Coronary artery disease (CAD) is the leading cause of fatalities worldwide. Nuclear factor (NF)‑κB is a transcription factor that controls cell proliferation, differentiation and immunity. To the best of our knowledge, the present study is the first investigation of the association between CAD and NF‑κB1 ‑94 W/D/NF‑κBIA 3'‑untranslated region (3'‑UTR) A→G polymorphisms. The study population comprised 226 CAD patients and 201 controls. There was no significant difference in NF‑κB1A 3'‑UTR A→G in the allele and genotype frequencies between case and control populations. The D allele frequency of NF‑κB1 ‑94 in the case group was significantly higher compared to the control group (P=0.028, odds ratio=1.37). The genotype frequency of NF‑κB1 ‑94 DD in the case group was significantly higher compared to the controls (P=0.028). Linkage analysis showed a close linkage among these 2 genes (P<0.001 for case and control), and AD and GD haplotypes were associated with CAD (P<0.001; P=0.015, respectively). NF‑κB1 ‑94 DD genotype can be a significant risk factor for the development of CAD.