Abrogation of Fv-1 restriction by genome-deficient virions produced by a retrovirus packaging cell line

作者：Lawrence R. Boone, Cynthia L. Innes, Catherine K. Heitman · 发表于：Journal of Virology · 年份：1990 · DOI：10.1128/jvi.64.7.3376-3381.1990 · 被引用次数：31 · 研究领域：HIV Research and Treatment、HIV/AIDS drug development and treatment、Monoclonal and Polyclonal Antibodies Research

The Fv-1b-mediated restriction of N-tropic retrovirus vector infection of BALB/3T3 cells was partially abrogated by prior infection with N-tropic murine leukemia virus. Likewise, abrogation of the Fv-1b restriction of N-tropic murine leukemia virus replication was accomplished by prior infection with genome-deficient virions produced by an N-tropic murine leukemia virus packaging cell line. The latter observation suggests that the Fv-1 target in genome-deficient virions abrogates Fv-1 restriction in the absence of any viral genome-directed processes.