Analogy between fibrinogen and casein. Effect of an undecapeptide isolated from k-casein on platelet function

作者：Pierre JOLLES, Sylviane Levy-Toledano, Anne‐Marie Fiat, Claudine Soria, Dieter Gillessen, Annick Thomaïdis, Fred W. Dunn, Jacques Caen · 发表于：European Journal of Biochemistry · 年份：1986 · DOI：10.1111/j.1432-1033.1986.tb09764.x · 被引用次数：181 · 研究领域：Protein Hydrolysis and Bioactive Peptides、Food Allergy and Anaphylaxis Research、Platelet Disorders and Treatments

A large number of similarities have previously been noted between the blood and milk clotting phenomena [Jollès, P. (1975) Mol. Cell. Biochem. 7, 73-85; Jollès, P. & Henschen, A. (1982) Trends Biochem. Sci. 7, 325-328]: some analogous features have also been found between fibrinogen and kappa-casein. In this connection, the effect of a natural and a synthetic peptide derived from kappa-casein on platelet function was studied: the undecapeptide Met-Ala-Ile-Pro-Pro-Lys-Lys-Asn-Gln-Asp-Lys (residues 106----116 of cow kappa-casein) inhibited both aggregation of ADP-treated platelets and binding of 125I-fibrinogen to ADP-treated platelets: its behaviour was similar to that of the structurally related C-terminal dodecapeptide of human fibrinogen gamma-chain.