Dietary compound isoliquiritigenin prevents mammary carcinogenesis by inhibiting breast cancer stem cells through WIF1 demethylation

作者：Neng Wang, Zhiyu Wang, Yu Wang, Xiaoming Xie, Jiangang Shen, Cheng Yun Peng, Jieshu You, Peng Fei Fu, Hailin Tang, Xin‐Yuan Guan, Jianping Chen · 发表于：Oncotarget · 年份：2015 · DOI：10.18632/oncotarget.3396 · 被引用次数：76 · 研究领域：Epigenetics and DNA Methylation、Histone Deacetylase Inhibitors Research、Genomics, phytochemicals, and oxidative stress

// Neng Wang 1, * , Zhiyu Wang 1, 2, * , Yu Wang 3 , Xiaoming Xie 4 , Jiangang Shen 1 , Cheng Peng 5 , Jieshu You 1 , Fu Peng 1 , Hailin Tang 4 , Xinyuan Guan 6 , Jianping Chen 1, 5 1 School of Chinese Medicine, Li Ka Shing Faculty of Medicine, the University of Hong Kong, Hong Kong 2 Department of Mammary Disease, Guangdong Provincial Hospital of Chinese Medicine, The Second Clinical Medical College, Guangzhou University of Chinese Medicine, Guangdong, China 3 Department of Pharmacology, Li Ka Shing Faculty of Medicine, the University of Hong Kong, Hong Kong 4 Department of Breast Oncology, Sun Yat-sen University Cancer Center; State Key Laboratory of Oncology in South China; Collaborative Innovation Center of Cancer Medicine, Guangzhou, China 5 School of Pharmaceutical Science, Chengdu University of Traditional Chinese Medicine, Sichuan, Chengdu, China 6 Department of Clinical Oncology, Li Ka Shing Faculty of Medicine, the University of Hong Kong, Hong Kong * These authors have contributed equally to this work Correspondence to: Jianping Chen, e-mail: jpjpchen@yahoo.com Keywords: mammary tumorigenesis, cancer stem cells, WIF1 demethylation, DNMT1, Isoliquiritigenin Received: December 25, 2014 Accepted: February 15, 2015 Published: March 26, 2015 ABSTRACT Breast cancer stem cells (CSCs) are considered as the root of mammary tumorigenesis. Previous studies have demonstrated that ISL efficiently limited the activities of breast CSCs. However, the cancer prevention activities o...