The eae gene of Citrobacter freundii biotype 4280 is necessary for colonization in transmissible murine colonic hyperplasia

作者：David B. Schauer, Stanley Falkow · 发表于：Infection and Immunity · 年份：1993 · DOI：10.1128/iai.61.11.4654-4661.1993 · 被引用次数：181 · 研究领域：Escherichia coli research studies、Probiotics and Fermented Foods、Bacterial Genetics and Biotechnology

Transmissible murine colonic hyperplasia is characterized by proliferation of anchored stem cells in the mucosa of the descending colon of laboratory mice and is caused by Citrobacter freundii biotype 4280. This bacterium produces attaching and effacing lesions in the descending colon prior to the onset of gross hyperplasia. By mutational analysis, the chromosomal eae gene of C. freundii biotype 4280 was shown to be necessary for colonic colonization. Conversely, bacteria cured of a 65-kb plasmid, which was identified in C. freundii biotype 4280, were not attenuated for colonic colonization or for the induction of colonic hyperplasia.