Biological activities of toxins A and B of Clostridium difficile

作者：David M. Lyerly, Donald Lockwood, S H Richardson, T D Wilkins · 发表于：Infection and Immunity · 年份：1982 · DOI：10.1128/iai.35.3.1147-1150.1982 · 被引用次数：259 · 研究领域：Clostridium difficile and Clostridium perfringens research、Botulinum Toxin and Related Neurological Disorders、Herbal Medicine Research Studies

Examination of the biological activities of the two known toxins of Clostridium difficile revealed that one of the toxins (toxin A) elicited a hemorrhagic fluid response in rabbit intestinal loops and a positive fluid response in infant mice. The other toxin (toxin B) did not produce a significant fluid response in either model, although the toxin was more lethal in infant mice. Both toxins elicited erythematous and hemorrhagic skin reactions and increased vascular permeability in rabbit skin.