Translating Molecular Recognition into a Pressure Signal to enable Rapid, Sensitive, and Portable Biomedical Analysis

作者：Zhi Zhu, Zhichao Guan, Dan Liu, Shasha Jia, Jiuxing Li, Zhi‐Chao Lei, Shui‐Chao Lin, Tianhai Ji, Zhong‐Qun Tian, Chaoyong Yang · 发表于：Angewandte Chemie International Edition · 年份：2015 · DOI：10.1002/anie.201503963 · 被引用次数：177 · 研究领域：Biosensors and Analytical Detection、Analytical Chemistry and Sensors、Advanced biosensing and bioanalysis techniques

Herein, we demonstrate that a very familiar, yet underutilized, physical parameter—gas pressure—can serve as signal readout for highly sensitive bioanalysis. Integration of a catalyzed gas-generation reaction with a molecular recognition component leads to significant pressure changes, which can be measured with high sensitivity using a low-cost and portable pressure meter. This new signaling strategy opens up a new way for simple, portable, yet highly sensitive biomedical analysis in a variety of settings.