Injectable Self‐Healing Glucose‐Responsive Hydrogels with pH‐Regulated Mechanical Properties

作者：Volkan Yesilyurt, Matthew J. Webber, Eric Andrew Appel, Colin Godwin, Róbert Langer, Daniel G. Anderson · 发表于：Advanced Materials · 年份：2015 · DOI：10.1002/adma.201502902 · 被引用次数：604 · 研究领域：Hydrogels: synthesis, properties, applications、Supramolecular Self-Assembly in Materials、Graphene and Nanomaterials Applications

Dynamically restructuring pH-responsive hydrogels are synthesized, employing dynamic covalent chemistry between phenylboronic acid and cis-diol modified poly(ethylene glycol) macromonomers. These gels display shear-thinning behavior, followed by a rapid structural recovery (self-healing). Size-dependent in vitro controlled and glucose-responsive release of proteins from the hydrogel network, as well as the biocompatibility of the gels, are evaluated both in vitro and in vivo.