Expression and functional significance of the J11d marker on mouse thymocytes.

作者：Ian Nicholas Crispe, Michael John Bevan · 发表于：The Journal of Immunology · 年份：1987 · DOI：10.4049/jimmunol.138.7.2013 · 被引用次数：213 · 研究领域：T-cell and B-cell Immunology

Subpopulations of thymocytes have been characterized phenotypically and functionally in relation to their expression of the marker defined by the monoclonal antibody J11d. Cortical-type L3T4+, Lyt-2+ thymocytes are all J11d+. Thymocytes that share the phenotype L3T4-, Lyt-2+ with peripheral Lyt-2+ T cells contain a J11d+ and a J11d- subset. These J11d- cells behave like peripheral Lyt-2+ T cells in two functional assays: they form clonal growth bursts in response to immobilized antibody against the T cell antigen receptor, and they act as precursors of alloreactive cytotoxic T cells. The J11d+ cells are inert in both of these assays. In contrast, L3T4+, Lyt-2- thymocytes do not contain a J11d+ subset.