Clinical use of a standard kit-preparation of radiolabeled monoclonal antibody 96.5 in the diagnostic imaging of metastatic melanoma.

作者：Mansoor Noorali Saleh, D M Miller, Laura Peterson, Charles D. Russell, MICHAEL W. UNGER, Marshall M. Urist, Richard H. Wheeler, AF LoBuglio · 发表于：Journal of Clinical Oncology · 年份：1988 · DOI：10.1200/jco.1988.6.6.1059 · 被引用次数：13 · 研究领域：Monoclonal and Polyclonal Antibodies Research、Radiopharmaceutical Chemistry and Applications、Cell Adhesion Molecules Research

We studied the efficiency of a standard-kit preparation using 1 mg 111In-labeled 96.5 monoclonal antibody in combination with 19 mg of unlabeled antibody in the diagnostic imaging of 27 patients with documented metastatic melanoma. Twenty-three of 26 patients (88%) demonstrated immunoscintigraphic localization of tumor. Of 104 metastatic sites previously documented by conventional studies, 62 (60%) were identified by immunoscintigraphy. A total of 77 sites demonstrated localization of radiolabeled antibody. Fifty-four (70%) corresponded to known sites of disease; eight sites (10%) were "discovered" by immunoscintigraphy and subsequently confirmed by conventional studies; 15 imaged sites (20%) could not be confirmed by conventional studies. Size and location of metastasis appear to be important features that influence imaging efficiency. Tumor size (greater than or equal to 2 cm v less than 2 cm) appears to be the statistical dominant determinant. The feasibility and potential clinical use of radioimmune imaging of tumors is discussed.