Effect of alendronate on alveolar bone resorption and angiogenesis in rats with experimental periapical lesions

作者：Haofei Xiong, Lili Wei, Yuanming Hu, Chao Zhang, Bin Peng · 发表于：International Endodontic Journal · 年份：2010 · DOI：10.1111/j.1365-2591.2010.01703.x · 被引用次数：46 · 研究领域：Bone health and treatments、Dental Radiography and Imaging、Bone health and osteoporosis research

AIM: To investigate the effects of systemically administered alendronate, one of the most potent bisphosphonates (BPs), on alveolar bone resorption and angiogenesis in rats subjected to experimental periapical lesions over two time periods. METHODOLOGY: Forty adult Sprague-Dawley (SD) rats were divided equally into control and experimental groups, and the pulp chambers of mandibular first molars of all rats were exposed to the oral environment to induce periapical lesions. The experimental group received daily subcutaneous injections of alendronate at a dose of 0.25 mg kg(-1), whereas the control group received only the saline vehicle. These injections were initiated 1 week before the periapical lesion induction and then continued daily throughout the entire experimental period. After 2 or 4 weeks following pulp exposure, the rats were killed, and the mandibles were examined histologically for periapical bone loss area, number of microvascular vessels (NMV) and tartrate-resistant acid phosphatase (TRAP) activity. RESULTS: Overall, periapical bone loss area and the number of TRAP-positive cells (osteoclasts) were significantly decreased at 2 and 4 weeks, respectively, after daily subcutaneous injection of alendronate compared with the control group (P < 0.05). There was no significant decrease change in NMV (P > 0.05). CONCLUSIONS: Administration of alendronate to rats might inhibit alveolar bone resorption associated with periapical disease, which might not lead to impairment...