IL-19 Induced Th2 Cytokines and Was Up-Regulated in Asthma Patients

作者：Sheng-Chin Liao, Yung-Chih Cheng, Yo-Ching Wang, Chiung-Wen Wang, S.M. Yang, Chun‐Keung Yu, Chi-Chang K. Shieh, Kuo-Chen Cheng, Meng-Feng Lee, Shyh‐Ren Chiang, Jiunn-Min Shieh, Ming‐Shi Chang · 发表于：The Journal of Immunology · 年份：2004 · DOI：10.4049/jimmunol.173.11.6712 · 被引用次数：189 · 研究领域：Asthma and respiratory diseases、IL-33, ST2, and ILC Pathways、Dermatology and Skin Diseases

IL-19 belongs to the IL-10 family, which includes IL-10, IL-19, IL-20, IL-22, melanoma differentiation-associated gene-7 (IL-24), and AK155 (IL-26). IL-10 has been shown to inhibit allergen-induced airway hyperreactivity and inflammation. To determine whether IL-19 was also associated with asthma, we used ELISA to analyze the serum level of IL-19 in patients with asthma and found that their serum IL-19 levels were twice those of healthy controls. Patients with a high level of IL-19 also had high levels of IL-4 and IL-13. In a dust mite-induced murine model of asthma, we found that IL-19 level in asthmatic BALB/cJ mice was also twice that of healthy control mice. IL-19 transcript was also induced in the lungs of asthmatic mice. Electroporation i.m. of the IL-19 gene into healthy mice up-regulated IL-4 and IL-5, but not IL-13. However, IL-19 up-regulated IL-13 in asthmatic mice. In vitro, IL-19 induced IL-4, IL-5, IL-10, and IL-13 production by activated T cells. Activation of T cells was required for induction of IL-13 because IL-19 did not induce IL-13 production on nonstimulated T cells. Taken together, these results demonstrated that IL-19 up-regulates Th2 cytokines on activated T cells and might play an important role in the pathogenesis of asthma.