Implications of DNA replication for eukaryotic gene expression

作者：Alan P. Wolffe · 发表于：Journal of Cell Science · 年份：1991 · DOI：10.1242/jcs.99.2.201 · 被引用次数：108 · 研究领域：Genomics and Chromatin Dynamics、DNA Repair Mechanisms、Epigenetics and DNA Methylation

DNA replication has a key role in many developmental processes. Recent progress in understanding events at the replication fork suggests mechanisms for both establishing and maintaining programs of eukaryotic gene activity. In this review, I discuss the consequences of replication fork passage for preexisting chromatin structures and describe how the mechanism of nucleosome assembly at the replication fork may facilitate the formation of either transcriptionally active or repressed chromatin.