β-catenin mutation is correlated with a favorable prognosis in patients with hepatocellular carcinoma

作者：Zheng Wang, Yuan‐Yuan Sheng, Xiaomei Gao, Chaoqun Wang, Xiangyu Wang, Xu Lu, Jinwang Wei, Kaili Zhang, Qiongzhu Dong, Lun–Xiu Qin · 发表于：Molecular and Clinical Oncology · 年份：2015 · DOI：10.3892/mco.2015.569 · 被引用次数：51 · 研究领域：Wnt/β-catenin signaling in development and cancer、Hepatocellular Carcinoma Treatment and Prognosis、Cancer Mechanisms and Therapy

The β-catenin gene is frequently mutated in patients with hepatocellular carcinoma (HCC) and has long been thought to be one of the major oncogenes involved in the hepatocarcinogenesis. The prognostic role of β‑catenin mutation in HCC remains unclear. To address this issue, a search for relevant studies was performed in the PubMed, Embase and Web of Science databases. The pooled effect was calculated from the available data to evaluate the correlation of β‑catenin mutation with overall survival rate and tumor clinicopathological features in patients with HCC. The pooled odds ratio (OR) was calculated using the Mantel‑Haenszel model for fixed effects. Three studies met the inclusion criteria. A total of 618 cases were included, and β‑catenin mutation was identified in 104 of them. The meta‑analysis revealed that the presence of β‑catenin mutation (n=104), compared with the control group (n=514), was correlated with a longer overall survival rate [OR, 0.33; 95% confidence interval (CI), 0.21‑0.53; P<0.00001] in patients with HCC. No significant heterogeneity was found among the eligible studies (I2=0%; P=0.72). β‑catenin mutation was correlated with a relatively lower rate of hepatitis B virus infection (OR, 0.36; 95% CI, 0.21‑0.61; P=0.0002), improved tumor differentiation (OR, 0.32; 95% CI, 0.19‑0.56; P<0.0001) and a lower tumor‑node‑metastasis stage (I+II) (OR, 0.23; 95% CI, 0.14‑0.38; P<0.00001). These findings suggest that β‑catenin mutation may predict a favorable prognos...