Optimal achieved blood pressure in acute intracerebral hemorrhage

作者：Hisatomi Arima, Emma Heeley, Candice Delcourt, Yoichiro Hirakawa, Xia Wang, Mark Woodward, Thompson Robinson, Christian Stapf, Mark Parsons, Pablo M. Lavados, Yining Huang, Ji‐Guang Wang, John Chalmers, Craig S. Anderson, For the INTERACT2 Investigators, C.S. Anderson, John Chalmers, Hisatomi Arima, Stephen M. Davis, Emma Heeley, Yining Huang, Pablo M. Lavados, Bruce Neal, Mark Parsons, R. Lindley, Lewis B. Morgenstern, T. Robinson, Christian Stapf, Christophe Tzourio, J.G. Wang, Yining Huang, Sheng Chen, X.Y. Chen, Li Cui, Z. Liu, Chen Lu, Jiarui Wang, Shengjie Wu, E. Xu, Q. Yang, C. Zhang, Jing Zhang, Ronny Beer, Erich Schmutzhard, P. Redondo, Markku Kaste, L. Soinne, Turgut Tatlisumak, Christian Stapf, Katja E. Wartenberg, S. Ricci, K. Klijn, Elsa Azevedo, Ángel Chamorro, Marcel Arnold, U. Fischer, Sanjiv Kaul, Jeyaraj Pandian, H. Boyini, Sally Singh, Alejandro A. Rabinstein, Conrado J. Estol, G. Silva, Pablo M. Lavados, Verónica V. Olavarría, T.G. Robinson, R. John Simes, M G Bousser, Graeme J. Hankey, Konrad Jamrozik, S.C. Johnston, Shun Li, Emma Heeley, C.S. Anderson, K. Bailey, John Chalmers, Johnny T. K. Cheung, C. Delcourt, S. Chintapatla, E. Ducasse, T. Erho, J. Hata, B. Holder, E. Knight, Richard I. Lindley, Michele LeRoux, T. Sassé, E. Odgers, R. C. Walsh, Z. Wolfowicz, C.S. Anderson, G. Chen, C. Delcourt, Stephanie Fuentes, R. Lindley, Bin Peng, H Schneble, M.-X. Wang, Hisatomi Arima, Laurent Billot, Stéphane Héritier, Q. Li, Mark Woodward, C. Delcourt, Ṣẹ̀yẹ Abímbọ́lá, S. Anderson, E. Chan, Georgina Cheng, P. Chmielnik, J. Hata, S. Leighton, J.-Y. Liu, Bodil Steen Rasmussen, Anitá Saxena, Sudeshna Tripathy, M. Armenis, M. A. Baig, B. Naidu, G. Starzec, S. Steley, Craig S. Anderson, Emma Heeley, Michele LeRoux, Candice Delcourt, T. Sassé, E. Knight, K. Bailey, Johnny T. K. Cheung, E. Odgers, E. Ducasse, B. Holder, Z. Wolfowicz, R. C. Walsh, S. Chintapatla, T. Erho, Conrado J. Estol, Anna Moles, A. Ruiz, Martina Zimmermann, J. Marinho, S. Alves, R. Angelim, Juliana Tavares de Araújo, L. Kawakami, Pablo M. Lavados, V.V. Olavarria, C. Bustos, Fernando Rodríguez González, Paula Muñoz Venturelli, Y. Huang, Xiaoling Chen, Yining Huang, Ran Jia, Nan Li, Shanshan Qu, Y. Shu, Anna Song, Jun Sun, J. Xiao, Yang Zhao, Jiangfeng Wang, Qiu-Sha Huang, C. Stapf, Éric Vicaut, A. Chamam, M.-C. Viaud, C. Dert, U. Fiedler, V. Jovis, S. Kabla, Serge Marchand, Alfonso de la Peña, V. Rochaud, K. Mallikarjuna, H. Boyini, N. Hasan, Eivind Berge, Else Charlotte Sandset, A. S. Forårsveen, Thompson Robinson, D. Richardson, Tarun Kumar, Shlomo Lewin, N. Poulter, John K. Field, Ayesha Anjum, A. Wilson, H. Perelmuter, A.M. Agarie, Andrés Barboza, Luciano Recchia, I.F. Miranda, S.G. Rauek, R. Duplessis, Helen M. Dewey, Laura Walker, S. Petrolo, C. Bladin, Jonathan Sturm, D Crimmins, D. V. Griffiths, Alexander Schütz, V. Zenteno, Mark Parsons, Ferdinand Miteff, Neil J. Spratt, Enda Kerr, Christopher Levi, Thanh G. Phan, Henry Ma, L. Sanders, Chris Moran, Kam Cheong Wong, Stephanie H. Read, Robert Henderson, Amy Wong, R. Hull, G. Skinner, Stephen M. Davis, Peter J. Hand, Bernard Yan, H. Tu, Benjamin R. Campbell, C.S. Anderson, C. Delcourt, David Blacker, Tissa Wijeratne, Manoji Pathirage, M. Jasinararchchi, Zelko Matkovic, Sherisse Celestino, F. Gruber, Milan R. Voško, E. Diabl, S. Rathmaier, Ronny Beer, Erich Schmutzhard, Bettina Pfausler, Raimund Helbok, Franz Fazekas, Robert Fischer, Birgit Poltrum, B. Zechner, U. Trummer, Matthieu Pierre Rutgers, André Peeters, Anne Dusart, Mehmet Duray, C. Parmentier, S. Ferrao-Santos, Raf Brouns, Sylvie De Raedt, Ann De Smedt, R.-J. Van Hooff, Jacques De Keyser, Sheila Cristina Ouriques Martins, A.G. de Almeida, R. Broudani, N.F. Titton, Gabriel R. de Freitas, F.M. Cardoso, Louise Giesel, Natália Almeida Lima, A.C. Ferraz de Almeida, Régis Gomes, T.S. Borges dos Santos, E.M. Veloso Soares, Osório Lopes Abath Neto, G.S. Silva, D. Gomes, F.A. de Carvalho, M. Miranda, A. Marques, Viviane Flumignan Zétola, G. de Matia, Marcos Christiano Lange, Jacqueline Montes, A. Reccius, Paula Muñoz Venturelli, V.V. Olavarria, Ana Belén García Soto, R. Rivas, C Klapp, Sergio Illanes, Carlos Aguilera, A. Castro, C. Figueroa, Jhonattan Benavides, P. Salamanca, Mauricio Concha, J. Pajarito, P. Araya, Federico Guerra, Yan Li, G. Liu, B. Wang, Jian Zhang, Yong Chong, Mingyi He, L. Wang, J. Liu, Xiaoyi Zhang, Chung‐Yu Lai, Hongfeng Jiang, Q. Yang, Shengjie Cui, Q. Tao, Y. Zhang, S. Yao, Min Xu, Y. Zhang, Z. Liu, H. Xiao, Jingmei Hu, Jun Tang, Jun Sun, H. Ji, Min Jiang, Feng Yu, Y. Zhang, X. Yang, Xinbiao Guo, Y. Wang, Longfei Wu, Z. Liu, Y. Gao, Dong Sun, Xiao‐Jun Huang, Y. Wang, L. Liu, Yan Li, Ping Li, Yang Jiang, Hongyang Li, Hui Lü, Jing Zhou, Cai Yuan, Xiaojing Qi, Feng Qiu, Haiyan Qian, Xiaogang Wang, J. Liu, Y. Huang, Wei Sun, Fei Li, R. Liu, Qiang Peng, Z. Ren, Chengcheng Fan, Y. Zhang, H. Wang, Tianqi Wang, Fanfan Shi, Chen Duan, Sheng Chen, J. Wang, Z. Chen, Xiao Tan, Z. Zhao, Y. Gao, J. Chen, Tao Han, Shengjie Wu, L. Zhang, L. Wang, Qing Hu, Qing Hou, X. Zhao, L. Wang, Guo Zeng, L Ma, F. Wang, Sheng Chen, Li Zeng, Zhihui Guo, Yuanwei Fu, Yang Song, L. Tai, X. Liu, X. Su, Yingchang Yang, Rong Dong, Xu Yang, S. Tian, Shasha Cheng, Li Su, Xiaoliang Sunney Xie, Tongren Xu, Deqin Geng, X. Yan, Huizhou Fan, Naisi Zhao, S. Wang, Jinbo Yang, Jing Zhang, Min Yan, Li Li, Z. Li, Xiangyang Xu, F. Wang, Longfei Wu, Xinbiao Guo, Ying Lian, H. Sun, D. Liu, Ning Wang, Q. Tang, Z. Han, Lin Feng, Y. Cui, Jiayu Tian, Hsing‐Yi Chang, Xiangying Sun, Jiarui Wang, C. Liu, Z. Wen, E. Xu, Q. Lin, Xiaoyi Zhang, Lingli Sun, Baotian Hu, Mengchen Zou, Qiligeer Bao, X. Lin, L. Zhao, X. Tian, H. Wang, Xia Wang, X. Li, Li-dan Hao, Yifei Duan, R. Wang, Zilong Wei, J. Liu, Shuxun Ren, Hanyun Ren, Y. Wang, Yanhui Dong, Yangyang Cheng, Mengchen Zou, Wei Liu, Ji‐Sheng Han, C. Zhang, Zheng Zhang, Jingwei Zhu, Y. Wang, Q. Li, Jun Qian, Yan Sun, K. Liu, F. Long, X. Peng, Q. Zhang, Zong-Li Yuan, Chong Wang, Minqiang Huang, Jing Zhang, Fengyan Wang, Pengkang He, Yuyi You, Xia Wang, Qingyong Yang, H. Wang, Jun Xia, L. Zhou, Yinglong Hou, Y. Wang, L. Liu, Yong-Fen Qi, Ling Mei, R. Lu, G. Chen, L. Liu, Ping Li, Wei Liu, Shaonan Zhou, Jin Wang, L. Wang, Hongyang Li, S. Zhang, L. Wang, Runmei Zou, J. Guo, Mingyang Li, Wangru Wei, L. Soinne, Sami Curtze, Maria Saarela, Daniel Strbian, Filip Scheperjans, T. de Broucker, Christopher Henry, R. Cumurciuc, N. Ibos-Augé, Anne-Céline Zeghoudi, Francisco Picó, Olivier Dereeper, Marina Simian, Clément Boisselier, A. Mahfoud, Serge Timsit, F.-M. Merrien, Blanche Guillon, M. Sevin, Fanny Hérisson, C. Magne, Abdol A. Ameri, C. Cret, S. Stefanizzi, F. Klapzcynski, Christian Denier, Mariana Sarov-Rivière, C. Stapf, Peggy Reiner, Jérôme Mawet, Dominique Hervé, F. Buffon, Emmanuel Touzé, V. Domigo, Chantal Lamy, David Calvet, M. Pasquini, Sonia Alamowitch, Pascal Favrole, I.-P. Muresan, S. Crozier, Charlotte Rosso, C. Pirès, Anne Léger, S. Deltour, Charlotte Cordonnier, Hilde Hénon, Carlo Riccardo Rossi, Mathieu Zuber, Marie Bruandet, Ruben Tamazyan, Claire Join-Lambert, Eric Jüettler, Trudy Millard Krause, S. Maul, Matthias Endres, Gerhard J. Jungehülsing, Michael G. Hennerici, Martin Griebe, Tamara Sauer, K. Knoll, R. Huber, K. Knauer, C. Michael Knauer, S. Raubold, H. Schneider, H. Hentschel, C. Lautenschläger, Eik Schimmel, Imanuel Dzialowski, Christian Foerch, Matthias Lorenz, O.C. Singer, Igor Martins Santos, A. Hartmann, A. Hamann, Alexander Schacht, Bruce J. Schrader, A. Teíchmann, Katja E. Wartenberg, Thomas J. J. Mueller, Sławomir Jander, Michael Gliem, Claudia Boettcher, Michael Rosenkranz, Cynthia A Beck, Dörte Otto, Götz Thomalla, Bin Cheng, Kam Sing Wong, Thomas Leung, Y.O.Y. Soo, S. Prabhakar, S.R. Kesavarapu, P.K. Gajjela, R.R. K. Ummer, Maamoun Basheer, A. Andipet, Ashfaq Mohammed, Vishwajeet Pawar, S.S.K. Eranki, Jeyaraj Pandian, Y. Singh, Naseem Akhtar, Nomal Chandra Borah, M. Ghose, Nusrat Choudhury, N.R. Ichaporia, J. Shendge, S. Khese, Vijaya Pamidimukkala, P. Inbamuthaiah, Sushma Nuthakki, N.M.R. Tagallamudi, A.K. Gutti, Dheeraj Khurana, P. Kesavarapu, V. Jogi, Amita Garg, Damayanti Samanta, G.R.K. Sarma, Raghunandan Nadig, Thomas Mathew, M.A. Anandan, E. Caterbi, Andrea Zini, Milena Cavazzuti, Federica Casoni, Roberta Pentore, Francesca Maria Antonella Falzone, S. Ricci, Tatiana Mazzoli, Lisa Greco, C. Menichetti, F. Coppola, Silvia Cenciarelli, E. Gallinella, A. Mattioni, R Condurso, I. Sicilia, Mauro Zampolini, Francesco Corea, Mali Barbi, Costanza Proietti, Danilo Toni, A. Pieroni, A. Anzini, Anne Falcou, M. Demichele, Catharina J.M. Klijn, Arnstein Tveiten, Erik Thomas Thortveit, S. Pettersen, N. Holand, B. Hitland, Stein Harald Johnsen, Agnethe Eltoft, A. Kamal, Ambreen Iqrar, L. Ali, Dil Begum, G. Gama, Elsa Azevedo, L. Fonseca, G. Moreira, L.M. Veloso, Diego Pinheiro, Laura Gallego Paredes, C. Rozeira, Tiago Gregório, Tomás Segura, Ó. Ayo, Jorge García‐García, Inmaculada Feria-Vilar, I. Gómez Fernández, Ángel Chamorro, Sergio Amaro, Xabier Urra, Vı́ctor Obach, Álvaro Cervera, Yolanda Silva, Joaquı́n Serena, Mar Castellanos, Mikel Terceño, Cecile van Eendenburg, U. Fischer, Marcel Arnold, Anja Weck, Oliver Findling, R. Lüdi, Elizabeth A. Warburton, Diana J. Day, N. Butler, E. Bumanlag, S. Caine, A. Steele, Michael J. Osborn, Erin Dodd, Peggy Murphy, Bernard Esisi, Eli M. Brown, R. Hayman, V. K.V. Baliga, M. Minphone, J. Kennedy, Ian Reckless, George Pope, Rachel Teal, K. Michael, Dulka Manawadu, Lalit Kalra, Russell E. Lewis, B. Mistry, E. Cattermole, Ahamad Hassan, L. Mandizvidza, John Bamford, H. L. Brooks, C. Bedford, R.L. Whiting, Paul Baines, Maha Hussain, Mark Harvey, K. Fotherby, Simon McBride, Paula Bourke, D. Morgan, Karla Jennings-Preece, Christopher Price, S. Huntley, V.E. Riddell, G. Storey, Rachel Lakey, G. Mani Subramanian, Damian Jenkinson, Joseph Kwan, Olivier David, Divya Tiwari, Martin James, Sharon Keenan, H. Eastwood, Louise Shaw, Philip Kaye, D. Button, B. Madigan, D. Williamson, A. Dixit, Joshua S. Davis, M.O. Hossain, Gary A. Ford, Adrian Parry‐Jones, V. O'Loughlin, R. Jarapa, Zin Naing, Caroline Lovelock, John O’Reilly, Usman Khan, Aneil Bhalla, A. G. Rudd, Jonathan Birns, David J. Werring, Ryan Law, Rebecca Perry, I. Jones, Renuka Erande, Christine Roffe, Indira Natarajan, Naveed Ahmad, K. Finney, J. Lucas, Amit Mistri, D. Eveson, Reginald Marsh, Victoria J. Haunton, T. Robinson, Alejandro A. Rabinstein, Jennifer Fugate, S. Lepore · 发表于：Neurology · 年份：2015 · DOI：10.1212/wnl.0000000000001205 · 被引用次数：137 · 研究领域：Intracerebral and Subarachnoid Hemorrhage Research、Traumatic Brain Injury and Neurovascular Disturbances、Neurosurgical Procedures and Complications

OBJECTIVES: To investigate the effects of intensive blood pressure (BP) lowering according to baseline BP levels and optimal achieved BP levels in patients with acute intracerebral hemorrhage (ICH). METHODS: INTERACT2 was an open, blinded endpoint, randomized controlled trial in 2,839 patients with ICH within 6 hours of onset and elevated systolic BP (SBP) (150-220 mm Hg) who were allocated to receive intensive (target SBP <140 mm Hg within 1 hour, with lower limit of 130 mm Hg for treatment cessation) or guideline-recommended (target SBP <180 mm Hg) BP-lowering treatment. Outcome was physical function across all 7 levels of the modified Rankin Scale at 90 days. RESULTS: Analysis of the randomized comparisons showed that intensive BP lowering produced comparable benefits on physical function at 90 days in 5 subgroups defined by baseline SBP of <160, 160-169, 170-179, 180-189, and ≥190 mm Hg (p homogeneity = 0.790). Analyses of achieved BP showed linear increases in the risk of physical dysfunction for achieved SBP above 130 mm Hg for both hyperacute (1-24 hours) and acute (2-7 days) phases while modest increases were also observed for achieved SBP below 130 mm Hg. CONCLUSIONS: Intensive BP lowering appears beneficial across a wide range of baseline SBP levels, and target SBP level of 130-139 mm Hg is likely to provide maximum benefit in acute ICH. CLASSIFICATION OF EVIDENCE: This study provides Class I evidence that the effect of intensive BP lowering on physical function is ...