Determinants of response to eucapneic hyperventilation with cold air in a population-based study.

作者：Ira Bruce Tager, Scott T. Weiss, Alvaro Muñoz, Carolyn Welty, Frank E. Speizer · 发表于：PubMed · 年份：1986 · DOI：10.1164/arrd.1986.134.3.502 · 被引用次数：49 · 研究领域：Chronic Obstructive Pulmonary Disease (COPD) Research

A population-based, epidemiologic investigation conducted in children, adolescents, and young adults analyzed the response to eucapneic hyperventilation with cold air as a continuous variable to better define factors that influence the expression of bronchial responsiveness. Among respiratory illness/symptom variables, only the report of asthma or persistent wheeze in the previous year and the report of a respiratory illness that led to activity restriction were significantly associated with response to cold air. Furthermore, a low, prechallenge FEF/FVC ratio was a significant predictor of response, especially among those subjects who reported a respiratory illness that led to activity restriction. This relationship was not observed for a low prechallenge FEF.