Risk Factors in Dengue Shock Syndrome

作者：Soe Thein, Myo Min Aung, Than Nu Shwe, Myo Aye, Aung Zaw, Kathy Aye, Khin Mar Aye, John Aaskov · 发表于：American Journal of Tropical Medicine and Hygiene · 年份：1997 · DOI：10.4269/ajtmh.1997.56.566 · 被引用次数：368 · 研究领域：Mosquito-borne diseases and control、Dengue and Mosquito Control Research、Malaria Research and Control

Despite a growing body of evidence predominantly, but not exclusively, from Thailand suggesting that the risk of developing dengue shock syndrome (DSS) is greatest following an anamnestic dengue infection, particularly if the most recent infection was with dengue 2 virus, there continues to be debate about the justification for these claims. This report describes a five-year, prospective study in two townships (suburbs) in Yangon (Rangoon) Myanmar (Burma) in which attempts were made to confirm the data from an earlier prospective study in Thailand and to address some of the criticism of earlier studies. This investigation found the incidence of anamnestic dengue infections in DSS patients to be significantly higher than in the community from which they were drawn and a significantly higher risk of developing DSS following an anamnestic infection (particularly with dengue 2 virus) than following a primary infection with any serotype.