High-visfatin levels in women with polycystic ovary syndrome: evidence from a meta-analysis

作者：Yifan Sun, Zhitong Wu, Lili Wei, Chunming Liu, Shengbo Zhu, Shifu Tang · 发表于：Gynecological Endocrinology · 年份：2015 · DOI：10.3109/09513590.2015.1056140 · 被引用次数：47 · 研究领域：Ovarian function and disorders、Adipokines, Inflammation, and Metabolic Diseases、Regulation of Appetite and Obesity

OBJECTIVE: Previous studies regarding visfatin levels in women with polycystic ovary syndrome (PCOS) showed conflicting results. To evaluate the visfatin levels in PCOS, a meta-analysis was performed. METHODS: A comprehensive literature search of eligible studies in Embase, Pubmed and the Cochrane Library was undertaken through November 2014. Standardized mean differences (SMDs) with 95% confidence intervals (CIs) were calculated to estimate the strength of the association. RESULTS: A total of 1341 subjects (695 cases and 646 controls) were included in this meta-analysis. The pooled analysis results indicated that the visfatin levels were significantly higher in PCOS patients than that of controls (SMD = 1.19, 95% CI 0.77-1.60, p = 0.000). The results from stratified analysis and univariate analysis suggested that high-visfatin levels were not related to body mass index (BMI), insulin resistance (IR) and total testosterone ratio. Significant heterogeneity was observed in all analysis. CONCLUSION: Our results indicate that high-circulating visfatin level is an intrinsic characteristic of PCOS, which suggests visfatin could be a potential biomarker for PCOS.