Long non-coding RNA UCA1 induces non-T790M acquired resistance to EGFR-TKIs by activating the AKT/mTOR pathway in EGFR -mutant non-small cell lung cancer

作者：Ningning Cheng, Weijing Cai, Shengxiang Ren, Xuefei Li, Qi Wang, Hui Pan, Mingchuan Zhao, Jiayu Li, Yishi Zhang, Chao Zhao, Xiaoxia Chen, Fei Ke, Caicun Zhou, Fred R. Hirsch · 发表于：Oncotarget · 年份：2015 · DOI：10.18632/oncotarget.4361 · 被引用次数：149 · 研究领域：Cancer-related molecular mechanisms research、RNA modifications and cancer、Cholangiocarcinoma and Gallbladder Cancer Studies

// Ningning Cheng 1,* , Weijing Cai 1,* , Shengxiang Ren 1 , Xuefei Li 2 , Qi Wang 1 , Hui Pan 1 , Mingchuan Zhao 1 , Jiayu Li 1 , Yishi Zhang 1 , Chao Zhao 2 , Xiaoxia Chen 1 , Ke Fei 3 , Caicun Zhou 1 and Fred R. Hirsch 4 1 Department of Medical Oncology, Shanghai Pulmonary Hospital, Tongji University, Tongji University Medical School Cancer Institute, Shanghai, P. R. China 2 Department of Lung Cancer and Immunology, Shanghai Pulmonary Hospital, Tongji University, Tongji University Medical School Cancer Institute, Shanghai, P. R. China 3 Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University, Tongji University Medical School Cancer Institute, Shanghai, P. R. China 4 Department of Medical and Pathology, University of Colorado Cancer Center, Aurora, Colorado, USA * These authors have contributed equally to this work Correspondence to: Caicun Zhou, email: // Keywords : UCA1, EGFR-TKIs, acquired resistance, non-small cell lung cancer Received : February 09, 2015 Accepted : June 01, 2015 Published : June 08, 2015 Abstract The aim of this study was to explore the role of long non-coding RNA UCA1 (urothelial cancer-associated 1) in acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors ( EGFR -TKIs) in EGFR -mutant non-small cell lung cancer (NSCLC). In our study, UCA1 expression was significantly increased in lung cancer cells and patients with acquired resistance to EGFR -TKIs. Over-expression of UCA1 was significantly associat...