Enzyme-catalysed conjugations of glutathione with unsaturated compounds

作者：Emma Jane Boyland, LF Chasseaud · 发表于：Biochemical Journal · 年份：1967 · DOI：10.1042/bj1040095 · 被引用次数：317 · 研究领域：Sulfur Compounds in Biology、Glutathione Transferases and Polymorphisms、Eicosanoids and Hypertension Pharmacology

1. Rat-liver supernatant catalyses the reaction of diethyl maleate with glutathione. 2. Evidence is presented that the enzyme involved is different from the known glutathione-conjugating enzymes, glutathione S-alkyltransferase, S-aryltransferase and S-epoxidetransferase. 3. Rat-liver supernatant catalyses the reaction of a number of other alphabeta-unsaturated compounds, including aldehydes, ketones, lactones, nitriles and nitro compounds, with glutathione: separate enzymes may be responsible for these reactions.