AN INQUIRY INTO THE ETIOLOGY OF ACUTE BRONCHIOLITIS OF INFANTS

作者：SARAH H. WOOD, G. John Buddingh, BENJAMIN F. ABBERGER · 发表于：PEDIATRICS · 年份：1954 · DOI：10.1542/peds.13.4.363 · 被引用次数：24 · 研究领域：Respiratory viral infections research、Tracheal and airway disorders、Congenital Diaphragmatic Hernia Studies

Tracheal aspirates and nasopharyngeal swabs obtained from 51 infants under 2 years of age with acute bronchiolitis were subjected to a careful bacteriologic study. The cases in this series were encountered during the 13 month period from November 1, 1951, to December 1, 1952. H. influenzae was recovered from 36 of the 51 infants. Of these, 26 proved to be H. influenzae type a and 6 proved to be H. influenzae type b. The four remaining were rough untypable strains. An increase in type specific antibody measured by a slide agglutination technic and by the Quellung reaction could be demonstrated in 46 infants. No increase in antibody titer could be demonstrated in 5. An increase in antibody titer to H. influenzae type a was demonstrated in 37 and to H. influenzae type b in 9 of the series. Combined bacteriologic and serologic evidence indicating that H. influenzae type a was involved in the infectious process was obtained in 26 cases. An increase in antibody titer to type a only was demonstrated in 11 others. In two from whom rough nontypable strains were isolated, an increase in titer to type a was demonstrated. Evidence for infection with type a was thus obtained in 37 of the 51 infants. From 2 infants H. influenzae type a was recovered but no increase in antibody titer could be demonstrated. Combined bacteriologic and serologic evidence for infection with H. influenzae type b was obtained in 5 infants. An increase in titer to type b was demonstrated in 2 others. A titer incre...