Cystatins — Inhibitors of Cysteine Proteinases

作者：Libuse A. Bobek, Michael J. Levine · 发表于：Critical Reviews in Oral Biology & Medicine · 年份：1992 · DOI：10.1177/10454411920030040101 · 被引用次数：155 · 研究领域：Oral microbiology and periodontitis research、Protease and Inhibitor Mechanisms、Salivary Gland Disorders and Functions

The cystatin superfamily of proteins, derived from a common ancestor, is comprised of a diverse group of potent cysteine proteinase inhibitors and antibacterial/viral agents grouped into several families. This review concentrates on family 2 cystatins, namely, the human salivary cystatins and cystatin C. Emphasis is given to their physicochemical and functional properties at both the protein and the molecular level. The role of cystatins in disease processes, including those in the oral cavity, is also discussed. Finally, future directions for cystatin research in oral biology are presented.