EXPERIMENTS ON FEEDING ADULT VOLUNTEERS WITH ESCHERICHIA COLI 111, B4, A COLIFORM ORGANISM ASSOCIATED WITH INFANT DIARRHEA

作者：W. W. FEEGUSON, E. C. JUNE · 发表于：American Journal of Epidemiology · 年份：1952 · DOI：10.1093/oxfordjournals.aje.a119510 · 被引用次数：78 · 研究领域：Viral gastroenteritis research and epidemiology

1. Adult human volunteers who were fed a mixture of 3 strains of Escherichia coli, 111, B4 in milk experienced symptoms similar to acute bacterial food poisoning when the dosage of organisms was large. Feeding 530,500,000 organisms or less produced a very mild illness or no effect. There was no evidence that a bacteremia developed or that the organisms were excreted in the urine. 2. A large percentage of volunteers who ingested E. coli 111, B4 strains developed serum agglutinins for the organism. Some who showed no symptoms developed agglutinins to some degree. 3. Volunteers who ingested a strain of E. coli isolated from a normal infant experienced no ill effects attributable to the feeding, although the number of organisms ingested was equal to the largest dose of E. coli 111, B4. No volunteer developed a rise in agglutinins for the normal coliform organism. 4. Although a carrier state can result from ingestion of E. coli 111, B4, the evidence of this study suggests that normal adults are resistant to infection under normal conditions. However, the view is advanced that E. coli 111, B4 may cause diarrhea in a debilitated adult.