One of the Antigenic Determinants of Paired Helical Filaments Is Related to Tau Protein1

作者：Nobuyuki Nukina, Yasuo Ihara · 发表于：The Journal of Biochemistry · 年份：1986 · DOI：10.1093/oxfordjournals.jbchem.a135625 · 被引用次数：340 · 研究领域：Microtubule and mitosis dynamics、Genetic Neurodegenerative Diseases、Amino Acid Enzymes and Metabolism

Paired helical filaments (PHF) are unusual neuronal fibers which accumulate progressively in the brain in Alzheimer's disease (AD). The insolubility of PHF in various kinds of solvents enabled us to obtain highly purified PHF, but prevented the application of conventional analytical methods to identify their components. Here we report that antibodies against purified PHF recognize tau protein, a brain-specific microtubule-associated protein, suggesting that a portion of PHF is tau protein.